Trinity College of Arts & Sciences 2005 - 2008 Professor in Psychology-Social and Health Sciences, Member of the Center for Brain Imaging and Analysis,ĭuke-UNC Center for Brain Imaging and Analysis, Professor of Medical Psychology in the Department of Psychiatry and Behavioral Sciences, The results also have implications for clinical translation, in terms of the identification of neural biomarkers for the diagnosis of neural pathology and targeting rehabilitation procedures. Ultimately, the research program can help link age-related changes in cognitive performance to changes in the structure and function of specific neural systems. It will be important to determine the relative influence of white matter pathway integrity, intrinsic functional connectivity, and task-related functional connectivity, as mediators of age-related differences in behavioral measures of cognitive performance. From DTI, information can be obtained regarding how anatomical connectivity constrains intrinsic functional connectivity. These latter measures, referred to as intrinsic functional connectivity, are beginning to show promise as an index of overall brain functional efficiency, which can be assessed without the implementation of a specific cognitive task. The white matter tracts of the brain provide critical pathways linking the gray matter regions, and thus this work will complement the studies using PET and fMRI that focus on gray matter activation.Ī current focus of the research program is the functional connectivity among regions, not only during cognitive task performance but also during rest. DTI is a recently developed technique that images the structural integrity of white matter. The PET and fMRI measures provide information regarding neural activity during cognitive performance. The behavioral measures are necessary to define the cognitive abilities of interest, and the neuroimaging techniques help define the functional neuroanatomy of those abilities.
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The cognitive abilities of interest include selective attention as measured in visual search tasks, semantic and episodic memory retrieval, and executive control processes. The behavioral measures have focused on reaction time, with the goal of distinguishing age-related changes in specific cognitive abilities from more general effects arising from a slowing in elementary perceptual processes. Take a look at the currently trending celebrities, the most popular birthdays for a specific day or jump to a random or recently added celebrity's page if you're not looking for anything specific.My research focuses primarily on the cognitive neuroscience of aging: the investigation of age-related changes in perception, attention, and memory, using both behavioral measures and neuroimaging techniques, including positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI). Start a scrapbook of everyone born on your birthday or give a gift of a scrapbook of everyone born on a loved one's birthday.
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